4.4 Article

Tandem cyclization-[3+3] cycloaddition reactions of 2-alkynylbenzaldoxime: synthesis of fused 1,2-dihydroisoquinolines

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 2, Pages 198-200

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.10.121

Keywords

2-Alkynylbenzaldoxime; Dimethyl cyclopropane-1,1-dicarboxylate; 1,2-Dihydroisoquinoline; Silver triflate; Yetterbium triflate

Funding

  1. National Natural Science Foundation of China [20772018]
  2. Shanghai Pujiang Program
  3. Program for New Century Excellent Talents in University [NCET-07-0208]

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Tandem cyclization-[3+3] cycloaddition of 2-alkynylbenzaldoximes with dimethyl cyclopropane-1,1-dicarboxylate co-catalyzed by AgOTf and Yb(OTf)(3) is described, which provides an useful method for the synthesis of tetrahydro-1,2-oxazine fused 1,2-dihydroisoquinolines. (C) 2008 Elsevier Ltd. All rights reserved.

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