Journal
TETRAHEDRON LETTERS
Volume 50, Issue 51, Pages 7220-7222Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.10.055
Keywords
Multicomponent reaction; Amidoalkyl naphthols; P2O5; Solvent free one-pot synthesis; Moderate temperature
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Funding
- Council of Scientific and Industrial Research (CSIR), New Delhi
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An atom-efficient and environment-friendly approach for the synthesis of amidoalkyl naphthols (4a-x) via multicomponent one-pot reaction of 2-naphthol (1), aromatic aldehyde (2) and amide (3) catalyzed by P2O5 has been developed. The present approach offers several advantages such as reduced reaction times, moderate temperature, higher yields, eco-friendly reaction condition, easy purification and economic availability of the catalyst. (C) 2009 Elsevier Ltd. All rights reserved.
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