4.4 Article

Co-catalyst enhancement of enantioselective PTC Michael additions involving glycine imines

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 26, Pages 3363-3365

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.02.123

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Funding

  1. EPSRC
  2. GlaxoSmithKline
  3. Engineering and Physical Sciences Research Council [GR/S86129/01, EP/D064295/1] Funding Source: researchfish
  4. EPSRC [EP/D064295/1] Funding Source: UKRI

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In this Letter we demonstrate that the Use of 2,41,6-trimethylphenol (mesitol) as a co-catalyst facilitates highly enantioselective addition of benzophenone glycine imine tert-butyl ester to a range of Michael acceptors. (C) 2009 Elsevier Ltd. All rights reserved.

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