Journal
TETRAHEDRON LETTERS
Volume 50, Issue 26, Pages 3463-3466Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.02.195
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Funding
- MEXT
- Honjo International Scholarship Foundation
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Nickel/Lewis acid binary catalysis is found effective to direct regioselective alkenylation of imidazoles through C-H bond activation and stereoselective insertion of alkynes. Use of P(t-Bu)(3) as a ligand allows exclusive regioselective C(2)-alkenylation, while PCyp(3) is found effective for C(5)-alkenylation of C(2)-substituted imidazoles. The reaction demonstrates a broad scope of imidazoles and internal alkynes to give trisubstituted ethenes highly regio- and stereoselectively in modest to good yields. (C) 2009 Elsevier Ltd. All rights reserved.
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