4.4 Article

1,3-Dipolar cycloaddition of arynes with azomethine imines: synthesis of 1,2-dihydropyrazolo[1,2-a]indazol-3(9H)-ones

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 28, Pages 4067-4070

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.04.102

Keywords

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Funding

  1. National Institute of General Medical Sciences [GM070620, GM079593]
  2. National Institutes of Health Kansas University Center of Excellence in Chemical Methodology and Library Development [P50 GM069663]

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A [3+2] 1,3-dipolar cycloaddition reaction of arynes with stable azomethine imines has been developed. The reaction rapidly assembles tricyclic pyrazoloindazolone derivatives in moderate yields under mild reaction conditions. (C) 2009 Elsevier Ltd. All rights reserved.

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