Journal
TETRAHEDRON LETTERS
Volume 50, Issue 47, Pages 6476-6479Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.09.013
Keywords
Isoquinolines; Indium; Barbier reaction; delta-Ketonitriles
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Funding
- Korean Government (MOEHRD) [KRF-2008-313-C00487]
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We developed an efficient synthetic strategy of poly-substituted 1-arylisoquinolines via an indium-mediated Barbier type allylation from delta-ketonitriles. Initial attack of allylindium species Occurred at the nitrile group selectively to form the enamine intermediate, which reacted with the ketone group intramolecularly to furnish the isoquinolines. (C) 2009 Elsevier Ltd All rights reserved.
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