Journal
TETRAHEDRON LETTERS
Volume 50, Issue 48, Pages 6658-6660Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.09.076
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Funding
- Niagara University Academic Center for Integrated Science
- Rochester Academy of Science
- Barbara S. Zimmer Memorial Research Award
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Reductive amination is a chemical reaction commonly employed by organic chemists in academics and the pharmaceutical industry. In this reaction a carbonyl group is converted to an amine via an imine intermediate, the formation of which is rate limiting. A major reagent necessary for the completion of this reaction is a hydride source, commonly sodium cyanoborohydride (Na(CN)BH3). The objective of this research was to compare the efficacy of Na(CN)BH3 with silica-bound cyanoborohydride (Si-CBH) as hydride sources in reductive amination reactions. Work has shown that reactions employing Si-CBH as a hydride source showed significant improvement, exhibiting an average percent conversion 25% greater than reactions using Na(CN)BH3. (C) 2009 Elsevier Ltd. All rights reserved.
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