Journal
TETRAHEDRON LETTERS
Volume 50, Issue 47, Pages 6572-6575Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.09.047
Keywords
Multicomponent reaction; Organocatalysis; Microwave; Knoevenagel; Hetero Diels-Alder
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Funding
- Fondazione Monte dei Paschi di Siena
- University of Siena
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A rapid protocol for the multicomponent microwave-assisted organocatalytic domino Knoevenagel/hetero Diels-Alder reaction (DKHDA) has been developed for the synthesis of 2,3-dihydropyran[2,3-c]pyrazoles. The reported procedure could he used for the fast generation of novel substituted 2,3-dihydropyran[2,3-c]pyrazoles with potential anti-tuberculosis activity. (C) 2009 Elsevier Ltd All rights reserved
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