Journal
TETRAHEDRON LETTERS
Volume 50, Issue 36, Pages 5094-5097Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.06.104
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Funding
- National Natural Science Foundation [20802078]
- National Basic Research Program of China [2009CB940900]
- Guangdong Natural Science Foundation [8151066 302000008]
- NN-CAS Research Foundation [NNCAS-2008-8]
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Di-t-butylimidodicarbonates can be chemoselectively and efficiently deprotected to the corresponding mono-BOC-protected amines in high yields using a catalytic amount of bismuth(III) bromide in acetonitrile at room temperature. This method is mild and compatible with the presence of a wide range of functional and other Protecting groups in the substrates, such as TBDMS, MOM and mono-BOC or Cbz-protected amines, etc. The method has advantages of ease of operation and use of nontoxic and inexpensive catalyst. (C) 2009 Elsevier Ltd. All rights reserved.
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