Journal
TETRAHEDRON LETTERS
Volume 50, Issue 39, Pages 5456-5458Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.07.038
Keywords
Multicomponent reactions; Barbier-like conditions; gamma-Butyrolactones; Aryl bromides; Aromatic aldehydes; Dimethyl itaconate
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Five-membered ring lactones have been synthesized using a straightforward three-component reaction among in situ-generated arylzinc reagents, dimethyl itaconate and aromatic aldehydes. This Barbier-like procedure. which is characterized by its simplicity, allows the concise synthesis of a range of highly functionalized 4,5-substituted gamma-butyrolactones. (C) 2009 Elsevier Ltd. All rights reserved.
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