4.4 Article

Preparation of 3,4-fused-spiro[furan-5(5H),4′-piperidin]-2-one

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 37, Pages 5228-5230

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.07.035

Keywords

Spiro piperidine; Suzuki coupling; Iodolactonization

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A general method for the preparation of various 3,4-fused-spiro[furan-5(5H),4'-piperidini-2-one with high yield is reported. The formation of spiro[furarione-piperidine] structure was achieved by a Suzuki coupling, followed by an iodolactonization reaction. (C) 2009 Elsevier Ltd. All rights reserved.

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