Journal
TETRAHEDRON LETTERS
Volume 50, Issue 35, Pages 4998-5000Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.06.088
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Funding
- Robert A. Welch Foundation [Y-1362]
- NSF [CHE-9601771, CHE-0234811]
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A short and operationally simple total synthesis of two Leucetta-derived marine alkaloids has been developed, which rely on position specific halogen-metal exchange to introduce the benzyl-substituted side chain. Introduction of the C2 amine group by lithiation and trapping with tosyl azide provides preclathridine A on catalytic hydrogenation. which can be converted to clathridine A by a procedure described in the literature. (C) 2009 Elsevier Ltd. All rights reserved.
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