Journal
TETRAHEDRON LETTERS
Volume 50, Issue 27, Pages 3970-3973Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.04.084
Keywords
Glycosylation; Lewis acid; Indium(III) chloride; Glycals; Disaccharides; Ferrier rearrangement
Categories
Funding
- Council of Scientific and Industrial Research, New Delhi, India
- IIT Delhi
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Anhydrous InCl3 has been shown to efficiently catalyze the Ferrier rearrangement by a direct allylic substitution of the hydroxyl group at C-3 position of glycals to afford the corresponding 2,3-unsaturated glycosides in high yields at ambient temperature. This methodology obviates the need for protecting and/or activating the C-3 hydroxyl group of glycals. The reaction works in equal ease with both 4,6-di-O-benzyl-D-glucal and 4,6-di-O-benzyl-D-galactal. The mildness of InCl3 makes this approach compatible for glycosyl acceptors with acid labile groups. The generality of the reaction has been demonstrated with a diversity of alcohols, phenols, and sugar nucleophiles. (C) 2009 Elsevier Ltd. All rights reserved.
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