Journal
TETRAHEDRON LETTERS
Volume 50, Issue 32, Pages 4616-4618Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.05.106
Keywords
2-Bromobenzaldehyde; Diethyl phosphite; 1,2-Dihydroiso-quinolin-1-ylphosphonate; Four-component reaction; Multicatalysis
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Funding
- National Natural Science Foundation of China [20772018]
- Shanghai Pujiang Program
- Program for New Century Excellent Talents in University [NCET-07-0208]
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A tandem four-component reaction of 2-bromobenzaldehyde, alkyne, amine, and diethyl phosphite catalyzed by the combination of palladium and copper salts provides a facile and efficient route to 1,2-dihydroisoquinolin-1-ylphosphonate. A cascade Sonogashira-intramolecular cyclization-nucleophilic addition may be involved in the reaction process. (C) 2009 Elsevier Ltd. All rights reserved.
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