4.4 Article

A facile synthesis of α-substituted thiophenes from a functionalized 2-aminothiophene by homo- and cross-coupling reactions

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 32, Pages 4670-4673

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.06.006

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Funding

  1. Ministry of Education of the Slovak Republic-VEGA [1/4453/07, 1/4300/07]
  2. UK [UK/102/2009]

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A series of new a-substituted thiophenes with elongated pi-conjugation are prepared by homo- and cross-coupling reactions. An efficient one-step synthesis of a key intermediate, a substituted 2-iodothiophene, via aprotic diazotization of a Gewald-like 2-aminothiophene is reported. (C) 2009 Elsevier Ltd. All rights reserved.

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