4.4 Article

Nonenzymatic kinetic resolution of racemic α-hydroxyalkanephosphonates with chiral copper catalyst

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 37, Pages 5241-5244

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.07.003

Keywords

Kinetic resolution; Asymmetric benzoylation; alpha-Hydroxyalkanephosphonates; Chiral copper complex; Molecular recognition

Funding

  1. Ministry of Education, Science, Sports and Culture, Japan [19790017]
  2. Grants-in-Aid for Scientific Research [19790017] Funding Source: KAKEN

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Kinetic resolution of alpha-hydroxyalkanephosphonates was efficiently performed by benzoylation in the presence of copper(II) triflate and (R,R)-Ph-BOX as a catalyst with excellent s value of up to 286. (C) 2009 Elsevier Ltd. All rights reserved.

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