4.4 Article

Expedient synthesis of highly substituted α-pyrones from Baylis-Hillman adducts and their conversion to poly-substituted aromatics

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 36, Pages 5098-5101

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.06.124

Keywords

alpha-Pyrones; Baylis-Hillman adducts; Diels-Alder reaction; DMAD; DDQ

Funding

  1. Korean Government (MOEHRD) [KRF-2008-313-C00487]
  2. Korea Basic Science Institute, Gwangju branch

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An efficient synthetic protocol of fully substituted alpha-pyrones has been developed starting from the Baylis-Hillman adducts. Subsequent Diels-Alder reaction of the alpha-pyrones and DMAD produced poly-substituted aromatic compounds in high yields. (C) 2009 Elsevier Ltd. All rights reserved.

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