Synthesis of spiro-pyridones and spiro-quinolones by sequential palladium on carbon-catalyzed allylation and ring closing metathesis reactions

A rapid and efficient strategy for the preparation of spiro-pyridones and spiro-quinolones using sequential Pd(0)/C-catalyzed allylation and ring closing metathesis reactions is described. The developed protocol features a fully regioselective allylation at C3 taking advantage of the unusual reactivity of Pd(0)/C catalyst. Application of the present methodology in nucleoside chemistry has also been investigated. (c) 2008 Elsevier Ltd. All rights reserved.