Journal
TETRAHEDRON LETTERS
Volume 50, Issue 9, Pages 1020-1022Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.12.060
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alpha-Alkylidene-beta-lactams have been prepared in good to excellent yields by olefin cross-metathesis. Electron-poor alpha-methylene-beta-lactams undergo cross-metathesis more rapidly and efficiently than more electron-rich analogs. Significantly, tetrasubstituted alkenes have for the first time been accessed by CM reactions. (C) 2008 Elsevier Ltd. All rights reserved.
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