Mesoporous aluminosilicate nanocage-catalyzed three-component coupling reaction: an expedient synthesis of α-aminophosphonates

Here we demonstrate for the first time the synthesis of alpha-aminophosphonates through the three-component coupling reaction of aldehydes, amines, and diethyl phosphite by using highly acidic 3D mesoporous aluminosilicate nanocage catalyst, which gave excellent yield with a high selectivity in a short reaction time due to its high acidity, 3D pores, and a huge space in the nanocages. (c) 2009 Elsevier Ltd. All rights reserved.