Journal
TETRAHEDRON LETTERS
Volume 50, Issue 26, Pages 3543-3546Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.03.037
Keywords
Lipase; Kinetic resolution; Hydrofluorocarbon; Secondary alcohol; Biocatalysis
Categories
Funding
- INEOS Fluor
- EPSRC
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Three model secondary alcohols have been subjected to enzymatic kinetic resolution using three common lipases and a typical acyl donor. The resolutions were performed in two pressurised low-boiling hydrofluorocarbons, which are novel media for enzymatic reactions, and five conventional organic solvents. In general, higher yields, ee's and rates of reaction were observed in the hydrofluorocarbons. (C) 2009 Published by Elsevier Ltd.
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