4.4 Article

Direct asymmetric aldol reactions in brine using novel sulfonamide catalyst

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 22, Pages 2632-2635

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.03.053

Keywords

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Funding

  1. Ajinomoto Award in Synthetic Organic Chemistry, Japan
  2. Japan Society for the Promotion of Science [18590014]
  3. Grants-in-Aid for Scientific Research [18590014] Funding Source: KAKEN

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Direct asymmetric aldol reactions of aldehydes with ketones in the presence of a catalytic amount of sulfonamide 4 and trifluoroacetic acid afforded the corresponding anti-aldol products in moderate to excellent yields with 85-93% ee. (C) 2009 Elsevier Ltd. All rights reserved.

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