Journal
TETRAHEDRON LETTERS
Volume 50, Issue 26, Pages 3631-3634Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.03.081
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Funding
- Japan Society for the Promotion of Science [17310128, 17510178, 19310144]
- Suntory Institute for Bioorganic Research (SUNBOR Grant),
- Houansha Foundation
- Institute for Fermentation, Osaka (IFO)
- Grants-in-Aid for Scientific Research [19310144, 17510178, 17310128] Funding Source: KAKEN
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The synthesis of crosslinked peptidoglycan (PGN) fragments from Streptococcus pneumoniae cell wall was achieved. The immunostimulatory activities, including the induction of IL-6 and the stimulation of the intracellular receptor Nod2, were also determined. The crosslinked PGN fragments were not major human Nod2 ligands. (C) 2009 Elsevier Ltd. All rights reserved.
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