Journal
TETRAHEDRON LETTERS
Volume 50, Issue 1, Pages 57-59Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.10.080
Keywords
Copper catalyst; Benzoxazines; Three-component couplings; One-pot synthesis
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Funding
- National Natural Science Foundation of China [20572025]
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A convenient one-pot synthesis of 1,4-benzoxazines via three-component coupling and subsequent O-cyclization is reported. The present reaction provides an efficient protocol to functionalized 1,4-benzoxazine derivatives in good to high yields from aldehydes, amines and alkynes. Furthermore, the O-annulation process is completely regio- and stereoselective, only the six-membered rings and its Z-isomers were obtained. (C) 2008 Elsevier Ltd. All rights reserved.
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