Journal
TETRAHEDRON LETTERS
Volume 50, Issue 44, Pages 6029-6031Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.08.027
Keywords
Click reactions; Hemi-acetal formation; Azidation; alpha-Alkoxytriazoles
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Funding
- CSIR, New Delhi
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Aldehyde, alcohol, azide, and alkyne undergo smooth coupling by means of acetal formation, azidation, and a Subsequent 'click reaction' in the presence of copper(II) triflate and copper metal in acetonitrile to furnish alpha-alkoxy-1,2,3-triazoles in good yields. The method provides a convenient route to prepare a wide range of triazoles in a one-pot operation via a four-component reaction. (C) 2009 Elsevier Ltd. All rights reserved.
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