Journal
TETRAHEDRON LETTERS
Volume 50, Issue 46, Pages 6380-6382Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.08.090
Keywords
Aminodibenzoazepinone; Resolution; Diastereoselective crystallization; Menthylcarbamate; Epimerization
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An improved synthesis of (S)-7-amino-5H,7H-dibenzo[b,d]azepin-6-one (1), involving a selective crystallization of epimeric menthylcarbamates for the resolution step followed by simultaneous cleavage of the carbamate and the lactam protecting group is described. Epimerization conditions of the undesired epimer have also been determined. (C) 2009 Elsevier Ltd. All rights reserved.
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