4.4 Article

Synthesis of ent-gabosine E from D-mannose by intramolecular nitrone-olefin cycloaddition

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 49, Pages 6916-6918

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.09.154

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Intramolecular nitrone-olefin cycloaddition in a mannose template followed by N-O cleavage, quaternization of the resulting amine, and finally oxidative elimination of the amino group affords, after deprotection, ent-gabosine E in enantiomerically pure form. (C) 2009 Elsevier Ltd. All rights reserved.

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