Journal
TETRAHEDRON LETTERS
Volume 50, Issue 19, Pages 2171-2173Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.02.135
Keywords
Glycoaminonitriles; Cyclopropylamine; Titanium isopropoxide; Pyrrolidine
Categories
Funding
- Conseil Regional de Picardie
- Ministere Francais de la Recherche
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We have developed an expedient method for the synthesis of 2-aminocyclopropyl pyrrolidines from carbohydrate-derived alpha-aminonitriles involving up to five or six steps, the key step being the titanium-mediated aminocyclopropanation on the aminonitrile moiety, followed by cleavage of the protecting groups. (C) 2009 Elsevier Ltd. All rights reserved.
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