Journal
TETRAHEDRON LETTERS
Volume 50, Issue 17, Pages 1943-1946Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.02.049
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Funding
- Spanish Ministry of Science and Education [AYA2006-15648-C02-01]
- Grant Agency of Czech Republic [203/09/11193]
- Ministry of Education of Czech Republic
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A highly enantioselective organocatalytic synthesis of piperidines is reported. The reaction is catalyzed by simple and commercially available secondary amines, affording the corresponding adducts with high yields and enantioselectivities. Moreover, this reaction is used for the formal synthesis of (-)-Paroxetine, a blockbuster drug, in only three steps. (C) 2009 Elsevier Ltd. All rights reserved.
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