Journal
TETRAHEDRON LETTERS
Volume 50, Issue 2, Pages 208-211Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.10.118
Keywords
Multicomponent reaction; Aryne; One-pot synthesis; Pyrido[2,1-a]isoindole; Azomethine ylide
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Funding
- National Natural Science Foundation of China [20672095, 20732005]
- CAS Academician Foundation of Zhejiang Province
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Multicomponent reactions (MCRs) involving pyridines, alpha-bromo ketones, and silylaryl triflates as aryne precursors were investigated. The reactions could also be extended to isocluinoline or alpha-bromo ethyl acetate. Substituted pyrido[2,1-a]isoindoles or isoindolo[2,1-a]isoquinolines could be obtained from this routine, which may have potential applications in antitumor drugs and fluorescent material fields. (c) 2008 Elsevier Ltd. All rights reserved.
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