4.4 Article

Multicomponent reactions of pyridines, α-bromo carbonyl compounds and silylaryl triflates as aryne precursors: a facile one-pot synthesis of pyrido[2,1-a]isoindoles

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 2, Pages 208-211

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.10.118

Keywords

Multicomponent reaction; Aryne; One-pot synthesis; Pyrido[2,1-a]isoindole; Azomethine ylide

Funding

  1. National Natural Science Foundation of China [20672095, 20732005]
  2. CAS Academician Foundation of Zhejiang Province

Ask authors/readers for more resources

Multicomponent reactions (MCRs) involving pyridines, alpha-bromo ketones, and silylaryl triflates as aryne precursors were investigated. The reactions could also be extended to isocluinoline or alpha-bromo ethyl acetate. Substituted pyrido[2,1-a]isoindoles or isoindolo[2,1-a]isoquinolines could be obtained from this routine, which may have potential applications in antitumor drugs and fluorescent material fields. (c) 2008 Elsevier Ltd. All rights reserved.

Authors

I am an author on this paper
Click your name to claim this paper and add it to your profile.

Reviews

Primary Rating

4.4
Not enough ratings

Secondary Ratings

Novelty
-
Significance
-
Scientific rigor
-
Rate this paper

Recommended

No Data Available
No Data Available