4.4 Article

Total synthesis of a fully lipidated form of phosphatidyl-myo-inositol dimannoside (PIM-2) of Mycobacterium tuberculosis

Journal

TETRAHEDRON LETTERS
Volume 50, Issue 40, Pages 5664-5666

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.07.109

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Funding

  1. Novartis Institute for Tropical Diseases (NITD)
  2. National Research Foundation (NRF) of Singapore

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Using an orthogonal protecting group approach to resolve racemic myo-inositol directly as its D-mannoside, we report a [2+n]-glycan/phosphatidylation strategy to assemble a bis-palmityl, tuberculostearyl form of phosphatidyl-myo-inositol dimannoside (PIM-2). (C) 2009 Elsevier Ltd. All rights reserved.

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