Journal
TETRAHEDRON LETTERS
Volume 50, Issue 17, Pages 2019-2023Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2009.02.102
Keywords
Isodon pharicus; Labiatae; Bispseurata F; Pharicinins A-C; NMR data; Cytotoxicity
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Funding
- NSFC [30772637]
- NSFC-joint Foundation of Yunnan Province [U08326021]
- Chinese Academy of Sciences [KSCX2-YW-R-097, KSCX1-YW-R-25]
- Yong Academic and Technical Leader Raising Foundation of Yunnan Province [2006PY01-47]
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A phytochemical investigation of Isodon pharicus led to the isolation of a novel asymmetric ent-kauranoid dimer, bispseurata F (1), and three new diterpenoids, pliaricinins A-C (2-4). Their structures were elucidated by extensive spectroscopic analysis. Compound 1 features a unique linkage pattern of C-17 with C-11' to connect the two monomers. A possible biogenetic pathway of 1 was also proposed. Compounds 3 and 4 exhibited moderate inhibitory activity against NB4 and SH-SY5Y cell lines. (C 2009 Elsevier Ltd. All rights reserved.
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