4.4 Article

Lewis acid- and/or Lewis base-catalyzed [3+2] cycloaddition reaction: synthesis of pyrazoles and pyrazolines

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 48, Pages 6768-6772

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.09.037

Keywords

Ethyl diazoacetate; DABCO; Indium trichloride; Activated olefins; Baylis-Hillman adducts; Pyrazolines; Pyrazoles

Funding

  1. CSIR, New Delhi, India

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A facile, InCl3 and/or DABCO mediated 1, 3-dipolar cycloaddition of ethyl diazoacetate (EDA) with various activated olefins Under solvent-free conditions at ambient temperature to afford 3, 5-disubstituted pyrazolines and pyrazoles in moderate to good yields is reported. (C) 2008 Elsevier Ltd. All rights reserved.

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