4.4 Article

Practical route for N,O-heteroatom interchange in 3,5-disubstituted-4-nitroisoxazoles

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 6, Pages 941-944

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2007.12.019

Keywords

polyfunctional scaffolds; 4-Nitroisoxazole; heteroatom interchange

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Reaction of 3-methyl-4-nitro-5-alkylisoxazoles with hydroxylamine provides a practical means to interchange the N,O-heteroatoms on the isoxazole core thereby expanding the range of compounds obtainable from 3-methyl-4-nitro-5-styrylisoxazoles. (c) 2007 Elsevier Ltd. All rights reserved.

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