Journal
TETRAHEDRON LETTERS
Volume 49, Issue 52, Pages 7364-7367Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.10.025
Keywords
MCRs; Furo[3,2-c]chromenes; Pd-catalyzed; Cascade reaction
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Funding
- Shanghai Commission of Science and Technology [06PJ14112]
- Chinese Academy of Sciences [KSCX-2-YW-R-23]
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A novel one-pot three-component reaction for the synthesis of multisubstituted furo[3,2-c]chromenes using 3-(1-alkynyl)chromones, aryl iodides, and alcohols is developed via Pd-catalyzed cascade 1,4-addition and cyclization. This synthetic approach efficiently generates two C-O bonds and one C-C bond to construct diverse furo[3,2-c]chromenes structures. (C) 2008 Elsevier Ltd. All rights reserved.
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