Journal
TETRAHEDRON LETTERS
Volume 49, Issue 45, Pages 6457-6461Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.08.103
Keywords
Karlotoxin; Hemolytic toxin; Dinoflagellate; Amphidinol
Categories
Funding
- NIH [5P41GM076300-01, R01 A1057588]
- North Carolina Dept. of Health and Human Services [01505-04]
- NOAA-ECOHAB [MML-106390A]
- NCI [P30-CA-14236]
- NOAA [NA04NOS4780276]
- CDC [U50/CCU 323376]
- Maryland Department of Health and Mental Hygiene
- Center of Marine Biotechnology [08-192]
- ECOHAB [289]
- NSF
- NC Biotechnology Center
- Duke University
- NSF, Division of Biological Infrastructure [DBI-0100085]
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The karlotoxins (KmTxs) are a family of compounds produced by the dinoflagellate Karlodinium veneficum which cause membrane permeabilization. The structure of KmTx 1, determined using extensive 2D NMR spectroscopy, is very similar to that of the amphidinols and related compounds, though KmTx I features unique structural modifications of the conserved core region. The structure of KmTx I differs from that reported for KmTx 2, the only other reported karlotoxin to date, in lacking chlorination at its terminal alkene and possessing a hydrophobic arm that is two carbons longer. (C) 2008 Elsevier Ltd. All rights reserved.
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