Journal
TETRAHEDRON LETTERS
Volume 49, Issue 48, Pages 6827-6830Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.09.074
Keywords
CD1d; alpha-Galactosylceramides; IFN-gamma; KRN7000
Categories
Funding
- Ministry of Education, Culture, Sports, Science, and Technology (MEXT), Japan [20790108]
- Grants-in-Aid for Scientific Research [20790108] Funding Source: KAKEN
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RCAI-61, the 6'-O-methylated analog of KRN7000, and six other analogs with modified 6'-position of the galactose moiety of KRN7000 were synthesized to examine their bioactivity for mouse lymphocytes. Methyl alpha-D-galactopyranoside was the starting material for RCAI-58, 61, 64, 83, 85, and 86, while RCAI-87 was prepared from methyl beta-L-arabinopyranoside. Bioassay showed RCAI-61 to be a Much more potent stimulant of mouse lymphocytes than KRN7000 and RCAI-56 to induce the production of a large amount of IFN-gamma in vivo. (C) 2008 Elsevier Ltd. All rights reserved.
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