Journal
TETRAHEDRON LETTERS
Volume 49, Issue 42, Pages 6101-6103Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.08.012
Keywords
cyclohexyl isocyanide; 1,3-dicarbonyl compound; multi-component reaction; 1H-indole-4(5H)-ones
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A simple and efficient synthesis of 2-(cyclohexylamino)-6,7-dihydro-3-aryl-1H-indole-4(5H)-ones was achieved via a one-pot multi-component reaction of cyclohexyl isocyanide, an aldehyde, a 1,3-dicarbonyl compound, and ammonium acetate in the presence of a catalytic amount of KHSO4 in acetonitrile. (C) 2008 Elsevier Ltd. All rights reserved.
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