Journal
TETRAHEDRON LETTERS
Volume 49, Issue 48, Pages 6759-6761Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.07.156
Keywords
Photochemistry; Aryl azide; Singlet nitrene; Photoaffinity labeling; Fluoroquinolone
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Funding
- CONACyT [45936-Q]
- UASLP [C06-FRC-02-17.17]
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A novel reagent for photoaffinity labeling, 7-azido-1-ethyl-3-carboxylate-6,8-difluoroquinolone, was obtained by nucleophilic substitution of 1-ethyl-3-carboxylate-6,7,8-trifluoroquinolone. Photochemical reaction of this azide with diethyl amine gave 7-hydrazino-derivative as the major product. This compound was generated by singlet nitrene N-H insertion. In addition, 7-amino-1-ethyl-3-carboxylate-6,8-difluoroquinolone was also obtained. (C) 2008 Published by Elsevier Ltd.
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