4.4 Article

DCC-Celite hybrid immobilized solid support as a new, highly efficient reagent for the synthesis of O-alkyl hydrogen alkylphosphonates under solvent-free conditions

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 10, Pages 1656-1659

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.01.016

Keywords

phosphonate; dicyclohexyl carbodiimide (DCC); celite; chemical weapons convention; chemical warfare agents

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An efficient and solvent-free synthesis of O-alkyl hydrogen alkyl phosphonates is described. The methodology involves the condensation of alkyl phosphonic acids using DCC-Celite under solvent-free conditions. (c) 2008 Elsevier Ltd. All rights reserved.

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