Journal
TETRAHEDRON LETTERS
Volume 49, Issue 50, Pages 7100-7102Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.09.098
Keywords
PIFA; Quinolin-4-ones; Pyrazole; Estrogen receptor
Categories
Funding
- COST [D28/008/03]
- Universidad del Pais Vasco
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A facile and efficient preparation of pyrazoloquinolin-4-ones, as potential ligands for the estrogen receptor, via a PIFA [phenyliodine(III)bis(trifluoroacetate)] promoted cyclization reaction with overall yields up to 29% over six steps is described. The employed strategy, based on an electrophilic amidation reaction as the key step of the synthesis, allows the generation of a diverse array of derivatives. (C) 2008 Elsevier Ltd. All rights reserved.
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