Journal
TETRAHEDRON LETTERS
Volume 49, Issue 15, Pages 2457-2460Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.02.031
Keywords
CuCl; alcohol oxidation; selective oxidation; carboxylic acid; benzylic alcohols
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Direct oxidation of primary alcohols to the corresponding carboxylic acids is performed highly efficiently at room temperature with anhydrous tort-butyl hydroperoxide in the presence of a catalytic amount of easily available CuCl under ligand free conditions in acetonitrile. Benzylic alcohols are more reactive than aliphatic alcohols, and these benzylic alcohols are selectively oxidized to the corresponding acids in the presence of aliphatic alcohols such as 1-octanol and 1-decanol. (C) 2008 Elsevier Ltd. All rights reserved.
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