Journal
TETRAHEDRON LETTERS
Volume 49, Issue 31, Pages 4652-4654Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.05.057
Keywords
THF; C-H activation; coupling reaction; Lewis acid
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A novel coupling reaction between tetrahydrofuran and olefins is discovered, in which the consecutive C-C and C-Cl bond-forming process takes place via Rh-catalyzed/lewis acid-promoted C-H activation. This reaction could be developed into a straightforward and effective method for rapid access to 2-(2-chloro-2-arylethyl)-tetrahydrofuran compounds. (c) 2008 Elsevier Ltd. All rights reserved.
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