4.4 Article

Unexpected intramolecular cyclization of some 2′-aminochalcones to indolin-3-ones mediated by Amberlyst®-15

Journal

TETRAHEDRON LETTERS
Volume 49, Issue 34, Pages 5028-5031

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tetlet.2008.06.047

Keywords

2'-aminochalcones; Amberlyst (R)-15; 2-(pyridinylmethylene)-3-indolinones

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The intramolecular cyclization of 2'-aminochalcones derived from 2- and 4-Pyridinecarboxaldehydes was carried out in the presence of Amberlyst (R)-15/AcOH media. Unexpectedly, the reaction Proceeded through a 5-exo process turning into an alternative approach for the synthesis of 2-(pyridinylmethylene)indolin-3-ones. (c) 2008 Published by Elsevier Ltd.

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