Enantio selective formal synthesis of antitumor agent (+)-ottelione A

The enantio selective formal synthesis of a natural antitumor product, (+)-ottelione A, was achieved through a catalytic enantioselective Diels-Alder strategy. These endeavors have led to the synthesis of a variety of synthetic analogues of this biologically potent natural product. (c) 2008 Elsevier Ltd. All rights reserved.