4.4 Article

New prenylated indole alkaloids from fungus Penicillium sp derived of mangrove soil sample

Journal

TETRAHEDRON
Volume 70, Issue 25, Pages 3859-3863

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.04.043

Keywords

Penicillium sp.; Prenylated indole alkaloids; Mangrovamides; X-ray diffraction; Anti-acetylcholinesterase activity

Funding

  1. National Key Basic Research Program of China (973)'s Project [2010CB833800, 2011CB915503]
  2. National High Technology Research and Development Program (863 Program) [2012AA092104, 2013AA092901]
  3. National Natural Science Foundation of China [21302198, 31270402, 21172230, 30973679, 41376162, 41176148]
  4. Knowledge Innovation Program of Chinese Academy of Science [SQ201117, SQ201019]
  5. Guangdong Province-CAS Joint Research Program [2011B090300023, 2012B091100264]
  6. Guangdong Marine Economic Development and Innovation of Regional Demonstration Project [GD2012-D01-001, GD2012-D01-002]

Ask authors/readers for more resources

Three diprenylated indole alkaloids, mangrovamides A-C (1-3), featured a bicyclo [2.2.2] diazaoctane core and possessed a novel gamma-methyl proline and isoprene derived dimethyl gamma-pyrone functionalities hitherto unknown among the family of paraherquamides, were isolated from the fungus Penicillium sp., which was separated from a mangrove soil sample. The structures were elucidated based on NMR, X-ray, and CD methods. The possible biosynthetic pathway of these compounds is proposed. (C) 2014 Elsevier Ltd. All rights reserved.

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