4.4 Article

Palladium(II)-catalyzed Suzuki-Miyaura reactions of arylboronic acid with aryl halide in water in the presence of 4-(benzylthio)-N,N,N-trimethybenzenammonium chloride

Journal

TETRAHEDRON
Volume 70, Issue 21, Pages 3385-3389

Publisher

PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.03.098

Keywords

Suzuki-Miyaura coupling; Palladium(II); S-donor ligand; Aryl halide; Aqueous media; Arylboronic acid

Funding

  1. National Natural Science Foundation of China, China [21171124, 21171125, 21371126]
  2. State Key Laboratory of Organometallic Chemistry
  3. Shanghai Institute of Organic Chemistry
  4. Chinese Academy of Sciences [201201006]
  5. '333' Project of Jiangsu Province
  6. Priority Academic Program Development of Jiangsu Higher Education Institutions
  7. 'SooChow Scholar' Program of Soochow University
  8. Qin-Lan Project

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This work reported that Suzuki-Miyaura coupling reactions of arylboronic acid with aryl bromide or iodides were mediated by Pd(OAc)(2) and 4-(benzylthio)-N,N,N-trimethylbenzenammonium chloride in the presence of Na2CO3 in water under the mild conditions. The corresponding Suzuki-Miyaura coupling products were obtained in good to excellent yields. (C) 2014 Elsevier Ltd. All rights reserved.

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