Journal
TETRAHEDRON
Volume 70, Issue 19, Pages 3166-3171Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.03.051
Keywords
Sponge; Topsentia sp.; 3-Alkylpyridine alkaloid; Topsendine; Voltage-gated K+ channel
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Funding
- National Marine '863' Projects [2011AA09070102, 2013AA092902]
- National Natural Science Foundation of China [81273430, 21072204, 41306130, 81302692]
- SKLDR/SIMM Project [SIMM1203ZZ-03]
- China Postdoctoral Science Foundation Grant [2012M520956]
- EU 7th Framework Program-IRSES Project [246987]
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Six new 3-alkylpyridine alkaloids, topsendines A-F (1-6), and one new naturally occurring product, 2-methyl-12-(pyridine-3-yl)dodecanal (7), were isolated from an undescribed species of Hainan sponge Topsentia. The structures of the new compounds were determined by extensive 2D NMR experiments, HR-EI/ESI-MS spectrometry measurements, and by comparison of their NMR data with those of structurally related compounds in the literature. In bioassay, compounds 1, 3, and 5 showed inhibitory actions on delayed rectifier K+ currents (I-K) in rat acutely dissociated hippocampal neurons at the concentration of 100 mu M, with the percentage of inhibition of 85.9 +/- 3.9%, 87.1 +/- 4.4%, and 76.2 +/- 12.2%, respectively. (c) 2014 Elsevier Ltd. All rights reserved.
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