Journal
TETRAHEDRON
Volume 70, Issue 37, Pages 6444-6449Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.07.027
Keywords
Xylocarpus granatum; Limonoid; ECD calculation; PTP1B inhibition
Categories
Funding
- National Marine '863' Project [2011AA09070102, 2013AA092902]
- Natural Science Foundation of China [21021063, 81273430, 31070310]
- SKLDR/SIMM Project [SIMM 1203ZZ-03]
- Syngenta-SIMM-PhD Studentship Project
- SKLNM/CPU project [SKLNMKF 201412]
- EU [246987]
- Hungarian National Research Foundation [OTKA K105871, K81701]
- National Information Infrastructure Development Institute [NIIFI 10038]
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Two new pyridine-containing limonoids, xylogranatopyridines A and B (I and 2) and their formal precursor, prexylogranatopyridine (3) were isolated from the twigs and leaves of the Chinese mangrove, Xylocarpus granatum. Xylogranatopyridine B (2) possesses an unprecedented rearranged B-ring together with a seco-ring A, supporting the biogenetic connection of 1-2 with 3. The chemical structures were elucidated by means of detailed spectroscopic analysis and X-ray single-crystal diffraction. The absolute configurations were assigned using electronic solid-state circular dichroism (ECD) supported by time-dependent density functional theory (TDDFT) ECD calculations and X-ray analysis. Xylogranatopyridine A (1) exhibited a significant inhibitory activity against protein tyrosine phosphatase 1B (PTP1B) with an IC50 value of 22.9 mu M. This is the first report of PTP1B inhibitory activity of limonoids. (C) 2014 Elsevier Ltd. All rights reserved.
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