Journal
TETRAHEDRON
Volume 70, Issue 42, Pages 7795-7801Publisher
PERGAMON-ELSEVIER SCIENCE LTD
DOI: 10.1016/j.tet.2014.02.007
Keywords
Cycloheptapeptide; Streptomyces drozdowiczii; Anti-infective; Marine-derived actinomycete; Marformycins A-F
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Funding
- National Natural Science Foundation of China [41106138, 41206135]
- MOST [2012AA092104, 2010CB833805]
- CAS [XDA11030403, KSCX2-EW-G-12]
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Six cycloheptadepsipeptides, marformycins A-F (1-6), featuring a unique N-terminally formylated side chain and five non-proteinogenic amino acid residues, were isolated from the deep Sea-derived Streptomyces drozdowiczii SCSIO 10141. The previously unsolved absolute stereochemistry of 3 and 4 was determined and the structures of other four new congeners were elucidated by extensive spectroscopic, chiral-phase HPLC, and single-crystal X-ray diffraction analyses. Compounds 1-5 bear no cytotoxicity against a number of human tumor cell lines but show selective anti-infective activity against Micrococcus luteus. (C) 2014 Elsevier Ltd. All rights reserved.
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